5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-{5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-thiophen-2-yl}-pyridin-2-ylamine

반응식

[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:7]2[n:8][c:9]([CH3:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[cH:12]2)[s:6]1.[NH2:24][c:25]1[n:26][cH:27][c:28]([B:31]2[O:32][C:33]([CH3:34])([CH3:35])[C:36]([CH3:37])([CH3:38])[O:39]2)[cH:29][cH:30]1>>[c:2]1(-[c:28]2[cH:27][n:26][c:25]([NH2:24])[cH:30][cH:29]2)[cH:3][cH:4][c:5](-[c:7]2[n:8][c:9]([CH3:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[cH:12]2)[s:6]1

참가 물질

반응물 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

HCID 574688002-(5-Bromo-thiophen-2-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

생성물 1

HCID 247605105-{5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-thiophen-2-yl}-pyridin-2-ylamine

출처 및 근거

ORD 기록: ord-eb4fb962d9e44711998bf96dd38f8321
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

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