Dichloromethane → N2-(3-(Dimethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine

반응식

[CH3:1][N:2]([CH2:3][CH2:4][CH2:5][NH:6][c:7]1[n:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[c:15]([NH:17][CH:18]2[CH2:19][CH2:20][N:21]([C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[CH2:22][CH2:23]2)[n:16]1)[CH3:31].[Cl:39][CH2:40][Cl:41].[F:32][C:33]([F:34])([F:35])[C:36]([OH:37])=[O:38]>>[CH3:1][N:2]([CH2:3][CH2:4][CH2:5][NH:6][c:7]1[n:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[c:15]([NH:17][CH:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[n:16]1)[CH3:31]

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 58006221tert-Butyl 4-(2-(3-(Dimethylamino)propylamino)quinazolin-4-ylamino)piperidine-1-carboxylate

생성물 1

HCID 58006203N2-(3-(Dimethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine

출처 및 근거

ORD 기록: ord-0fb2735fcf55427ba009a2be2f159083
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

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