Allyl bromide → 5-(Allyloxy)-2-ethoxybenzonitrile

HRID 11263노트

반응식

HRID 11263 반응식
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:5]=1[C:6]#[N:7])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:19](Br)[CH:20]=[CH2:21]>CC(C)=O>[CH2:21]([O:12][C:9]1[CH:10]=[CH:11][C:4]([O:3][CH2:1][CH3:2])=[C:5]([CH:8]=1)[C:6]#[N:7])[CH:20]=[CH2:19]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 219731772-Ethoxy-5-hydroxybenzonitrile

생성물 1

HCID 219731885-(Allyloxy)-2-ethoxybenzonitrile

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

25 g of 2-ethoxy-5-hydroxybenzonitrile (153.2 mmol) (example 36A) and potassium carbonate (63.52 g, 459.6 mmol) are initially charged in 750 ml of acetone, 19.9 ml of allyl bromide (229.8 mmol) are added, and the mixture is stirred under reflux overnight. The mixture is filtered off and concentrated giving a mobile orange oil.

후처리

  1. temperatureunder reflux overnight
  2. filtrationThe mixture is filtered off
  3. concentrationconcentrated
  4. customgiving a mobile orange oil

출처 및 근거

ORD 기록
ord-a4f97ceaf626467dba55ac336b431903
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098207B2

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