Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Nitro-2-propoxyphenyl-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one → 2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Nitro-2-propoxyphenyl-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one | HCID 135604963 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 생성물 | 2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one | HCID 135604925 | — |
반응 단계
Analogously to the procedure of example 42A, 5.13 g (12.96 mmol) of the compound from example 43A are hydrogenated in tetrahydrofuran/ethanol (1:1) using 1.11 g of 10% Pd/C. The product is purified by silica gel chromalography using toluene and ethyl acetate as solvent gradient.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098207B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-4282992d9f884e20a0f83bdc2c8a2c5d |
| 출처 메모 | uspto-grants-2006_08 |