Pyridine → 2-[5-(3-Cyanobenzenesulfonamido)-2-propoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

HRID 11277

반응식

HRID 11277 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH2:26][CH3:27])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:10]3[N:9]=2)[CH:7]=1.[C:28]([C:30]1[CH:31]=[C:32]([S:36](Cl)(=[O:38])=[O:37])[CH:33]=[CH:34][CH:35]=1)#[N:29].N1C=CC=CC=1>O1CCCC1>[C:28]([C:30]1[CH:31]=[C:32]([S:36]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH2:26][CH3:27])=[C:6]([C:8]3[NH:13][C:12](=[O:14])[C:11]4=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]5[CH2:22][CH2:21][CH2:20][CH2:19]5)[N:10]4[N:9]=3)[CH:7]=2)(=[O:38])=[O:37])[CH:33]=[CH:34][CH:35]=1)#[N:29]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 28013603-Cyanobenzene-1-sulfonyl chlorideHCID 1356049252-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

생성물 1

HCID 1356049582-[5-(3-Cyanobenzenesulfonamido)-2-propoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

200 mg (0.566 mmol) of the compound from example 44A are reaccted with 342 mg (1.70 mmol) of 3-cyanobenzenesulfonyl chloride and 0.46 ml (5.66 mmol) of pyridine in 15 ml of tetrahydrofuran overnight.

출처 및 근거

ORD 기록
ord-3f190f042da046bd91a26572743fe5ea
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098207B2

연결된 노트

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