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Pyridine → 2-[5-(3,4-Dimethoxyphenylacetylamino)-2-ethoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

HRID 11279
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HRID 11279 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH3:26])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:10]3[N:9]=2)[CH:7]=1.[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH2:37][C:38](Cl)=[O:39])[CH:32]=[CH:33][C:34]=1[O:35][CH3:36].N1C=CC=CC=1>O1CCCC1>[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH2:37][C:38]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH3:26])=[C:6]([C:8]3[NH:13][C:12](=[O:14])[C:11]4=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]5[CH2:22][CH2:21][CH2:20][CH2:19]5)[N:10]4[N:9]=3)[CH:7]=2)=[O:39])[CH:32]=[CH:33][C:34]=1[O:35][CH3:36]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 1049PyridineHCID 3604458(3,4-Dimethoxyphenyl)acetyl chlorideHCID 1356049412-(5-Amino-2-ethoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

생성물 1

HCID 1356049512-[5-(3,4-Dimethoxyphenylacetylamino)-2-ethoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

Analogously to the preparation of example 46, 100 mg (0.283 mmol) of the compound from example 42A are reacted with 182 mg (0.849 mmol) of 3,4-dimethoxyphenylacetyl chloride and 0.23 ml (2.84 mmol) of pyridine in 6 ml of tetrahydrofuran.

출처 및 근거

ORD 기록
ord-0d637d190c36455992e0de19f9749e14
출처 데이터셋
uspto-grants-2006_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07098207B2

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