Methanol → methyl 4-iodo-1H-pyrrole-2-carboxylate

HRID 1128

반응식

HRID 1128 반응식
[I:1][C:2]1[CH:3]=[C:4](C(=O)C(Cl)(Cl)Cl)[NH:5][CH:6]=1.[CH3:13][OH:14].[CH3:15][O-:16].[Na+]>O.C(OCC)C>[I:1][C:2]1[CH:3]=[C:4]([C:13]([O:16][CH3:15])=[O:14])[NH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 116816022,2,2-trichloro-1-(4-iodo-1H-pyrrol-2-yl)ethan-1-one

생성물 1

HCID 11673249methyl 4-iodo-1H-pyrrole-2-carboxylate

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

후처리

  1. customthe reaction medium evaporated to dryness
  2. customthe residue obtained
  3. customThe organic phase was decanted off
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customThe residue obtained
  7. customwas triturated in heptane
  8. filtrationfiltered
  9. custom4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

출처 및 근거

ORD 기록
ord-2f9353d568ba495d9d6fa8a66d2c0875
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723499

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