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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 11294생성일: 2026년 10월 26일

5-Amino-1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid → 5-Amino-1-(2',4'-difluorophenyl)-6,8-difluoro-1,4-dihydro-7-(3'-hydroxy-5'-methylpyrrolidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

https://huagongshe.com/reaction/11294

반응식

참여 물질

역할이름HCID투입량
반응물5-Amino-1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acidHCID 14896552—
반응물5-Methylpyrrolidin-3-olHCID 21973779—
생성물5-Amino-1-(2',4'-difluorophenyl)-6,8-difluoro-1,4-dihydro-7-(3'-hydroxy-5'-methylpyrrolidin-1-yl)-4-oxo-quinoline-3-carboxylic acidHCID 1016113164%

반응 단계

The condensation of 5-Amino-1-(2′,4′-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 3-hydroxy-5-methylpyrrolidine in a similar manner as described in example 1 gave the titled product. Yield 64%, m.p ° C., C21H17F4N3O4, m/z 453. (M+1)

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07098219B2
출처 데이터셋uspto-grants-2006_08
ORD IDord-8eceacde241b40df8f1b4079320c969f
출처 메모uspto-grants-2006_08