1-(p-Methoxyphenyl)-2-propanone → 4-Dimethylamino-3-(4-methoxyphenyl)-3-buten-2-one

HRID 11320

반응식

HRID 11320 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=[O:12])[CH3:11])=[CH:5][CH:4]=1.OC[CH2:15][N:16]1[C:20](=O)C2=CC=CC=C2[C:17]1=O>CN(C)C=O>[CH3:15][N:16]([CH3:20])[CH:17]=[C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[C:10](=[O:12])[CH3:11]

참가 물질

4

반응물 2

HCID 312311-(p-Methoxyphenyl)-2-propanoneHCID 77499N-(2-Hydroxyethyl)phthalimide

생성물 1

HCID 539901024-Dimethylamino-3-(4-methoxyphenyl)-3-buten-2-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
85 °C

실험 절차

To a stirred solution of 1-(4-methoxy-phenyl)-propan-2-one (1, 8.37 g, 51.0 mmol) in N,N-dimethylformamide (200 mL) was added dimethoxymethyl-dimethyl-amine (2, 27 mL, 203 mmol). The reaction mixture was then stirred for 18 h at 85° C., allowed to cool to ambient temperature and excess solvent and reagents were removed under reduced pressure to give crude 4-dimethylamino-3-(4-methoxyphenyl)-but-3-en-2-one (3) as yellow oil which was used in the following step without further purification.

후처리

  1. temperatureto cool to ambient temperature
  2. customexcess solvent and reagents were removed under reduced pressure

출처 및 근거

ORD 기록
ord-ba9cd433d44c4544b97682e7fc2afe04
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098211B2

연결된 노트

불러오는 중…