Borane → 4-[5-[5-(1-aminoethyl)thiophen-2-yl]thiophen-2-yl]-5-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidin-2-amine

HRID 1132961노트

반응식

[BH3:1].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:2][O:3][N:4]=[C:5]([CH3:6])[c:7]1[cH:8][cH:9][c:10](-[c:12]2[s:13][c:14](-[c:17]3[n:18][c:19]([NH:24][CH:25]4[CH2:26][C:27]([CH3:33])([CH3:34])[NH:28][C:29]([CH3:31])([CH3:32])[CH2:30]4)[n:20][cH:21][c:22]3[CH3:23])[cH:15][cH:16]2)[s:11]1>>[NH2:4][CH:5]([CH3:6])[c:7]1[cH:8][cH:9][c:10](-[c:12]2[s:13][c:14](-[c:17]3[n:18][c:19]([NH:24][CH:25]4[CH2:26][C:27]([CH3:33])([CH3:34])[NH:28][C:29]([CH3:31])([CH3:32])[CH2:30]4)[n:20][cH:21][c:22]3[CH3:23])[cH:15][cH:16]2)[s:11]1

참가 물질

반응물 3

HCID 6331Borane

HCID 8028Tetrahydrofuran

HCID 727684464-[5-[5-(N-methoxy-C-methylcarbonimidoyl)thiophen-2-yl]thiophen-2-yl]-5-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidin-2-amine

생성물 1

HCID 112595934-[5-[5-(1-aminoethyl)thiophen-2-yl]thiophen-2-yl]-5-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidin-2-amine

출처 및 근거

ORD 기록: ord-d35e080e62f54a889696af76ab3e488f
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

반응 노트

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