Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → Rac-2-ethoxy-3-{1-[2-(4-isopropyl-phenyl)-thiazol-4-ylmethyl]-1h-indol-4-yl}-propionic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-Chloromethyl-2-(4-isopropyl-phenyl)-thiazole | HCID 2095697 | — |
| 반응물 | Rac-2-ethoxy-3-(1h-indol-4-yl)-propionic acid ethyl ester | HCID 69279879 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Rac-2-ethoxy-3-{1-[2-(4-isopropyl-phenyl)-thiazol-4-ylmethyl]-1h-indol-4-yl}-propionic acid ethyl ester | HCID 69284005 | — |
반응 단계
In analogy to the procedures described in examples 1 a] and 1 b], rac-2-ethoxy-3-(1H-indol-4-yl)-propionic acid ethyl ester was reacted with 4-chloromethyl-2-(4-isopropyl-phenyl)-thiazole in N,N-dimethylformamide in the presence of sodium hydride to yield rac-2-ethoxy-3-{1-[2-(4-isopropyl-phenyl)-thiazol-4-ylmethyl]-1H-indol-4-yl}-propionic acid ethyl ester, which was subsequently saponified to yield rac-2-ethoxy-3-{1-[2-(4-isopropyl-phenyl)-thiazol-4-ylmethyl]-1H-indol-4-yl}-propionic acid as light brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098228B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-6a9c12be0fc447c092c1a0877ee06089 |
| 출처 메모 | uspto-grants-2006_08 |