4-Hydroxybenzoic Acid → 4-(2-Propyloxyethoxy)benzoic Acid

HRID 11404

반응식

HRID 11404 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:17]([O:20][CH2:21][CH2:22]Cl)[CH2:18][CH3:19].O>CN(C)C=O>[CH2:17]([O:20][CH2:21][CH2:22][O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1)[CH2:18][CH3:19]

참가 물질

6

반응물 4

HCID 1354-Hydroxybenzoic AcidHCID 962WaterHCID 11430Potassium CarbonateHCID 1235061-(2-Chloroethoxy)propane

생성물 1

HCID 219742854-(2-Propyloxyethoxy)benzoic Acid수율 105.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-hydroxybenzoic acid (3.04 g) and anhydrous potassium carbonate (5.52 g) in N,N-dimethylformamide (20 ml) was added 2-propyloxyethyl chloride (2.94 g), and the mixture was stirred at room temperature overnight, and then stirred at 80° C. for 8 hours. To a reaction solution was added water, and then the mixture was extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous solution of sodium chloride, successively, dried and concentrated under reduced pressure to give the title compound (5.21 g; crude).

후처리

  1. stirringstirred at 80° C. for 8 hours
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materiala saturated aqueous solution of sodium chloride, successively, dried
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4cc1be09091443928f00b584eef1d8bf
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098234B2

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