Iodine → Methyl 4-amino-3-iodobenzoate

HRID 11415

반응식

HRID 11415 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.[I:12]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+2]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][C:11]=1[I:12]

참가 물질

5

반응물 2

HCID 807IodineHCID 12082Methyl 4-aminobenzoate

생성물 1

HCID 4104649Methyl 4-amino-3-iodobenzoate

시약·촉매·용매 2

HCID 178418844HCID 178418844, 화합물촉매HCID 702Ethanol용매

실험 절차

Methyl 4-aminobenzoate (30.23 g, 200 mmol) was added to a mixture of iodine (60.91 g, 240 mmol) and silver sulfate (81.07 g, 260 mmol) in 1 L of ethanol at room temperature. The mixture was stirred at room temperature for 18 hours, filtered over Celite and the filtrate was evaporated to dryness under reduced pressure. The residue was chromatographed on silica gel (230–400 mesh) and eluted with 1% ethyl acetate in hexane to give 35 g (63%).

후처리

  1. filtrationfiltered over Celite
  2. customthe filtrate was evaporated to dryness under reduced pressure
  3. customThe residue was chromatographed on silica gel (230–400 mesh)
  4. washeluted with 1% ethyl acetate in hexane
  5. customto give 35 g (63%)

출처 및 근거

ORD 기록
ord-f7ee27120d3e45df9a00b6188ab0a4c8
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098231B2

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