Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2-(Carbamoylamino)thiophene-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Trichloroacetyl isocyanate | HCID 76400 | — |
| 반응물 | 2-Aminothiophene-3-carboxamide | HCID 699495 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-(Carbamoylamino)thiophene-3-carboxamide | HCID 11171402 | — |
반응 단계
2-Amino-3-thiophencarboxamide (0.44 g) was suspended in acetonitrile (25 ml) and trichloroacetylisocyanate (0.2 ml) added dropwise with stirring over 10 minutes. Stirring was continued for a further 3 h at room temperature and then a solution of ammonia in methanol (10 ml of a 2M solution) was added and stirring was continued for a further 2 h. The solvent was evaporated and the residue treated with water. The resultant solid was filtered off and washed with more water. Trituration with ether gave the title urea (0.2 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098240B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-f0c8411110a14024be0381e63896f360 |
| 출처 메모 | uspto-grants-2006_08 |