Dichloromethane → [6-Bromo-1-(2-hydroxy-ethyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone

반응식

[Br:1][c:2]1[c:3]([O:35][CH:36]2[CH2:37][CH2:38][N:39]([CH:42]([CH3:43])[CH3:44])[CH2:40][CH2:41]2)[cH:4][c:5]2[cH:6][c:7]([C:21](=[O:22])[N:23]3[CH2:24][CH2:25][N:26]([S:29](=[O:30])(=[O:31])[CH:32]4[CH2:33][CH2:34]4)[CH2:27][CH2:28]3)[n:8]([CH2:11][CH2:12][O:13][Si:14]([C:15]([CH3:16])([CH3:17])[CH3:18])([CH3:19])[CH3:20])[c:9]2[cH:10]1.[Cl:52][CH2:53][Cl:54].[OH:45][C:46]([C:47]([F:48])([F:49])[F:50])=[O:51]>>[Br:1][c:2]1[c:3]([O:35][CH:36]2[CH2:37][CH2:38][N:39]([CH:42]([CH3:43])[CH3:44])[CH2:40][CH2:41]2)[cH:4][c:5]2[cH:6][c:7]([C:21](=[O:22])[N:23]3[CH2:24][CH2:25][N:26]([S:29](=[O:30])(=[O:31])[CH:32]4[CH2:33][CH2:34]4)[CH2:27][CH2:28]3)[n:8]([CH2:11][CH2:12][OH:13])[c:9]2[cH:10]1