홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Water → 2-[(1-Benzothien-4-yloxy)ethyl]morpholine

HRID 11427
노트
인쇄 미리보기

반응식

HRID 11427 반응식
Cl.ClCC[N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[S:11]1[C:15]2=[CH:16][CH:17]=[CH:18][C:19](O)=[C:14]2[CH:13]=[CH:12]1.[C:21](=[O:24])([O-])[O-].[K+].[K+].O.[CH3:28]N(C)C=O>>[S:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[C:19]([O:24][CH2:21][CH2:28][CH:9]3[O:8][CH2:7][CH2:6][NH:5][CH2:10]3)[C:14]=2[CH:13]=[CH:12]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 19217Benzo(b)thiophen-4-olHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

생성물 1

HCID 867602232-[(1-Benzothien-4-yloxy)ethyl]morpholine

반응 조건

온도
80 °C
이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

실험 절차

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

후처리

  1. temperatureAfter cooling
  2. extractionextracted twice with ethyl acetate
  3. washThe combined solvent phase was washed twice with brine
  4. dry with materialdried (magnesium sulphate)
  5. customevaporated

출처 및 근거

ORD 기록
ord-2afdbf5b452c4473aa1f7b3a5c5a3a04
출처 데이터셋
uspto-grants-2006_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07098240B2

반응 노트

불러오는 중…