3-(4-Fluorophenyl)-2,1-benzisoxazole → 2-Amino-4'-fluorobenzophenone

HRID 1148

반응식

HRID 1148 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][N:10]=[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)=[CH:4][CH:3]=1>O1CCCC1.C(N(CC)CC)C.[Pd]>[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)=[O:9]

참가 물질

5

반응물 1

HCID 196948213-(4-Fluorophenyl)-2,1-benzisoxazole

생성물 1

HCID 98372872-Amino-4'-fluorobenzophenone

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매HCID 8471Triethylamine용매

실험 절차

To a suspension of (16) (42.6 g, 0.2 mol) in 750 ml of dry tetrahydrofuran (THF) and 20 ml of triethylamine is added 5% palladium on charcoal (6 g). The vigorously stirred suspension is flushed with hydrogen gas and stirred at room temperature under a hydrogen atmosphere until absorption of hydrogen ceases (approximately 90-90% of the molar amount; 8-10 hours). The catalyst is removed by filtration through a bed of celite, and the solvent is removed under reduced pressure. The product (16) is recrystallized from toluene.

후처리

  1. customThe vigorously stirred suspension is flushed with hydrogen gas
  2. custom8-10 hours
  3. customThe catalyst is removed by filtration through a bed of celite
  4. customthe solvent is removed under reduced pressure
  5. customThe product (16) is recrystallized from toluene

출처 및 근거

ORD 기록
ord-92bc8cb4ed55424491eb833aaed1c16a
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723573

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