참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4'-Fluoroacetophenone | HCID 9828 | — |
| 반응물 | 2-Amino-4'-fluorobenzophenone | HCID 9837287 | — |
| 반응물 | 2-Methylbenzenesulfonic acid hydrate | HCID 12496995 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,4-Bis(4-fluorophenyl)quinoline | HCID 19694816 | — |
반응 단계
A flask is loaded with (17) (21.5 g, 0.1 mol), 4-fluoroacetophenone (13.8 g, 0.1 mol), and toluene sulfonic acid monohydrate (3.8 g, 0.02 mol). The flask is heated to 200° C. and the water of condensation removed. After water evolution ceased, the mixture is cooled and the crude solid product is crushed and washed with hot ethanol The product is further recrystallized from toluene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05723573 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-505bc94ed0b24d42b247b9173702273a |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
