Dichloromethane → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-7-methoxy-1,4-dihydro-2H-3,1-benzoxazin-2-one

반응식

[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:28][cH:29]1)[CH2:7][O:8][C:9](=[O:27])[N:10]2[CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([NH:19][C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:17][CH2:18]1.[Cl:37][CH2:38][Cl:39].[OH:30][C:31]([C:32]([F:33])([F:34])[F:35])=[O:36]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:28][cH:29]1)[CH2:7][O:8][C:9](=[O:27])[N:10]2[CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([NH2:19])[CH2:17][CH2:18]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 86642631tert-butyl{1-[2-(7-methoxy-2-oxo-2H-3,1-benzoxazin-1(4H)-yl)ethyl]piperidin-4-yl}carbamate

생성물 1

HCID 667737621-[2-(4-Aminopiperidin-1-yl)ethyl]-7-methoxy-1,4-dihydro-2H-3,1-benzoxazin-2-one

출처 및 근거

ORD 기록: ord-447dc182de8740168bb7a192020d66db
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

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