3-(Diethylamino)-1-propanol → Diethyl-[3-(2-fluoro-4-nitro-phenoxy)-propyl]-amine

HRID 11519

반응식

HRID 11519 반응식
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[CH2:12]([N:14]([CH2:19][CH3:20])[CH2:15][CH2:16][CH2:17][OH:18])[CH3:13]>>[CH2:12]([N:14]([CH2:19][CH3:20])[CH2:15][CH2:16][CH2:17][O:18][C:7]1[CH:6]=[CH:5][C:4]([N+:9]([O-:11])=[O:10])=[CH:3][C:2]=1[F:1])[CH3:13]

참가 물질

3

반응물 2

HCID 121593-(Diethylamino)-1-propanolHCID 1230531,2-Difluoro-4-nitrobenzene

생성물 1

HCID 21974931Diethyl-[3-(2-fluoro-4-nitro-phenoxy)-propyl]-amine

실험 절차

In a manner similar to that described in Example 231a, 3,4-difluoronitrobenzene (6.7 mL, 60.6 mmol, 1 equiv.) and 3-diethylamino-1-propanol (9 mL, 1 equiv.) are converted to the named compound as a brown oil (16.3 g).

출처 및 근거

ORD 기록
ord-56b3fcc70da64331a887512e770547de
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098236B2

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