HCID 13385546, 화합물 → 6-(Pyridin-4-yl)-4,5-dihydropyridazin-3(2H)-one

반응식

C([C:3]([N:17]1CCOCC1)([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[CH2:4][CH:5](C)[C:6](OC)=[O:7])#N.C(C(N1CCOCC1)(C1CCNCC1)CCC(OCC)=O)#[N:24]>>[N:14]1[CH:15]=[CH:16][C:11]([C:3]2[CH2:4][CH2:5][C:6](=[O:7])[NH:24][N:17]=2)=[CH:12][CH:13]=1

참가 물질

반응물 2

HCID 13385546HCID 13385546, 화합물

HCID 20436354Ethyl 4-cyano-4-(4-morpholinyl)-4-(4-piperidinyl)butanoate

생성물 1

HCID 127640636-(Pyridin-4-yl)-4,5-dihydropyridazin-3(2H)-one

실험 절차

Following the procedure described in Example 1 but using in place of methyl 4-cyano-2-methyl-4-(4-morpholinyl)-4-(4-pyridinyl)butanoate a molar equivalent quantity of ethyl 4-cyano-4-(4-morpholinyl)-4-(4-piperidinyl)butanoate [McEvoy et al., J. Org. Chem. 44, 4597 (4600)(1979)], it is contemplated that there can be obtained 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinone.

출처 및 근거

ORD 기록: ord-971fe5268cf34b9db196c1ed4095f47b
출처 데이터셋: uspto-grants-1984_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04486431

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