3-Fluoroaniline → 6-((3-Fluorophenyl)amino)-5,8-quinoxalinedione
반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]2[C:3]=1[N:4]=[CH:5][CH:6]=[N:7]2.[F:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17]>[Ag-]=O.C(O)C>[F:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH:17][C:10]1[C:9](=[O:12])[C:8]2[N:7]=[CH:6][CH:5]=[N:4][C:3]=2[C:2](=[O:1])[CH:11]=1참가 물질
5
실험 절차
Approximately one gram of 5,8-dihydroxyquinoxaline was dissolved in 100 ml. of 2B ethanol. To the solution were added about 5 g. of freshly prepared silver (I) oxide and about 3 g. of 3-fluoroaniline. The reaction was stirred overnight at room temperature and worked up in the same manner as described in Example 3. Crystallization from ethyl acetate gave about 500 mg. of the title compound.
후처리
- additionTo the solution were added about 5 g
- customCrystallization from ethyl acetate
- customgave about 500 mg
출처 및 근거
- ORD 기록
- ord-7171877cfe2b47b1bae01f044166c85b
- 출처 데이터셋
- uspto-grants-1984_12
- 특허 번호
- US04486432
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