4-(2-(Pyrrolidin-1-yl)ethoxy)aniline → HCID 178418755, 화합물

HRID 11539

반응식

HRID 11539 반응식
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:16][C:17]1[CH:25]=[C:24]2[C:20]([C:21](=[CH:27]O)[C:22](=[O:26])[NH:23]2)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:25]=[C:24]2[C:20]([C:21](=[CH:27][NH:15][C:12]3[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:14][CH:13]=3)[C:22](=[O:26])[NH:23]2)=[CH:19][CH:18]=1

참가 물질

3

반응물 2

HCID 64937494-(2-(Pyrrolidin-1-yl)ethoxy)anilineHCID 178418700HCID 178418700, 화합물

생성물 1

HCID 178418755HCID 178418755, 화합물수율 48.8%

실험 절차

In a manner similar to that described in Example 231, 4-(2-pyrrolidin-1-yl-ethoxy)-phenylamine (690 mg, 1.2 equiv.) and 6-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (500 mg, 2.79 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (500 mg, 48%).

후처리

  1. customare reacted

출처 및 근거

ORD 기록
ord-a2382c20b073413a90f8631784926c2c
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098236B2

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