Phenyl isocyanate → HCID 13201298, 화합물

HRID 1153967노트

반응식

HRID 1153967 반응식
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:10][C:11]1[CH:23]=[CH:22][C:14]([CH2:15][NH:16][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1>C(Cl)Cl>[F:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:15][N:16]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 834084HCID 834084, 화합물

생성물 1

HCID 13201298HCID 13201298, 화합물수율 90.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

6.1 g (0.05 mol) of phenyl isocyanate were added dropwise to a solution of 9.65 g (0.05 mol) of N-4-fluorobenzyl-N-cyclopentylamine in 80 ml of anhydrous methylene chloride, while cooling with ice and stirring. The mixture was stirred for 30 minutes at room temperature and for 30 minutes at 40° C., the solvent was stripped off in vacuo, and the residue was recrystallized from acetonitrile. 14.1 g of N-4-fluorobenzyl-N-cyclopentyl-N'-phenylurea of melting point 120° to 121° C. were obtained.

후처리

  1. temperaturewhile cooling with ice
  2. stirringThe mixture was stirred for 30 minutes at room temperature and for 30 minutes at 40° C.
  3. customthe residue was recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-2226323bb1de49758d3b89366ca8b415
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04487783

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