2-(4-Methylpiperidin-1-yl)ethan-1-amine → 6-[2-(4-Methyl-1-piperidinyl)ethylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine

HRID 1154018노트

반응식

HRID 1154018 반응식
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][N:13]=[CH:14][N:4]2[N:3]=1.[NH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([CH3:24])[CH2:20][CH2:19]1>>[CH3:24][CH:21]1[CH2:22][CH2:23][N:18]([CH2:17][CH2:16][NH:15][C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][N:13]=[CH:14][N:4]3[N:3]=2)[CH2:19][CH2:20]1

참가 물질

3

반응물 2

HCID 7837002-(4-Methylpiperidin-1-yl)ethan-1-amineHCID 126224416-Chloro-7,8,9,10-tetrahydro-[1,2,4]triazolo[3,4-a]phthalazine

생성물 1

HCID 133655956-[2-(4-Methyl-1-piperidinyl)ethylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine

실험 절차

A solution of 5.0 g of 6-chloro-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine in 25 ml of 1-(2-aminoethyl)-4-methylpiperidine was heated at reflux for 15 hours and then poured into ice water. The resulting off-white solid was separated by filtration and recrystallized from toluene to give 6-[2-(4-methyl-1-piperidinyl)ethylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine melting at about 180°-181° C.

후처리

  1. temperatureat reflux for 15 hours
  2. customThe resulting off-white solid was separated by filtration
  3. customrecrystallized from toluene

출처 및 근거

ORD 기록
ord-39e24a8f18f54868a7c4374f38390a54
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04487930

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