4-(2-(Pyrrolidin-1-yl)ethoxy)aniline → HCID 178419007, 화합물

HRID 11543노트

반응식

HRID 11543 반응식
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[C:20]2=[CH:27]O>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[C:20]2=[CH:27][NH:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:14][CH:13]=1

참가 물질

3

반응물 2

HCID 64937494-(2-(Pyrrolidin-1-yl)ethoxy)anilineHCID 1784190365-chloro-3-(hydroxymethylidene)-1H-indol-2-one

생성물 1

HCID 178419007HCID 178419007, 화합물수율 79%

실험 절차

In a manner similar to that described in Example 231, 4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine (632 mg, 1.2 equiv.) and 5-chloro-3-hydroxymethylene-1,3-dihydro-indol-2-one (500 mg, 2.56 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (775 mg, 79%).

후처리

  1. customare reacted

출처 및 근거

ORD 기록
ord-e4ed8fa2876743748633148fa540b5c2
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098236B2

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