2-(4-Chloro-2-butenyl)-1,3-isoindolinedione → N-[4-(1H-imidazol-1-yl)-2-butenyl]isoindole-1,3-(2H)-dione

HRID 1154341

반응식

HRID 1154341 반응식
Cl[CH2:2][CH:3]=[CH:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.[Na]>CN(C)C=O>[N:17]1([CH2:2][CH:3]=[CH:4][CH2:5][N:6]2[C:14](=[O:15])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]2=[O:16])[CH:21]=[CH:20][N:19]=[CH:18]1

참가 물질

4

반응물 2

HCID 27342002-(4-Chloro-2-butenyl)-1,3-isoindolinedioneHCID 57373095Imidazole sodium

생성물 1

HCID 54070864N-[4-(1H-imidazol-1-yl)-2-butenyl]isoindole-1,3-(2H)-dione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 23.5 g. of N-(4-chloro-2-butenyl)-isoindole-1,3(2H)-dione, 11.0 g. of sodium imidazole and 200 ml. of dimethyl formamide was heated on the steam bath for 18 hours and concentrated to remove the solvent; the residue was taken up in methylene chloride, washed with water, dried with magnesium sulfate and again concentrated. The residue was dissolved in hot ethylacetate and allowed to cool and N-[4-(1H-imidazol-1-yl)-2-butenyl]isoindole-1,3-(2H)-dione, m.p. 106°-108° C., was obtained.

후처리

  1. additionA mixture of 23.5 g
  2. concentrationconcentrated
  3. customto remove the solvent
  4. washwashed with water
  5. dry with materialdried with magnesium sulfate
  6. concentrationagain concentrated
  7. dissolutionThe residue was dissolved in hot ethylacetate
  8. temperatureto cool

출처 및 근거

ORD 기록
ord-f5ef5eafe588410697b3bd75a7663cdd
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04489089

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