Potassium Hydroxide → HCID 21292013, 화합물
반응식
[CH3:1][N:2]([CH2:4][C:5]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][NH:15]C=O)[CH:8]=[CH:7][CH:6]=1)[CH3:3].[OH-].[K+]>CO.C(OCC)C>[CH3:1][N:2]([CH2:4][C:5]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][NH2:15])[CH:8]=[CH:7][CH:6]=1)[CH3:3]참가 물질
5
실험 절차
N-[3-(6-dimethylaminomethyl-2-pyridyloxy) propyl]formamide (2.7 g, 0.013 mol) is added to a solution of 85% potassium hydroxide pellets (3.0 g) dissolved in methanol (30 ml) and heated at gentle reflux for 21 hours. The reaction is cooled, diluted with diethyl ether (30 ml), the precipitated salts filtered, and the solvent removed under vacuum. The residue is dissolved in water and the product exhaustively extracted into ethanol/chloroform, dried and evaporated to give 2.1 g of pure product.
후처리
- temperatureheated
- temperatureat gentle reflux for 21 hours
- temperatureThe reaction is cooled
- filtrationthe precipitated salts filtered
- customthe solvent removed under vacuum
- dissolutionThe residue is dissolved in water
- extractionthe product exhaustively extracted into ethanol/chloroform
- customdried
- customevaporated
출처 및 근거
- ORD 기록
- ord-c7ef9001d41a4d17b3b8667409eeed9b
- 출처 데이터셋
- uspto-grants-1984_12
- 특허 번호
- US04490533
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