5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 178483223, 화합물

HRID 1154724노트

반응식

HRID 1154724 반응식
CS[C:3]1[C:7]2=[CH:8][S:9][CH:10]=[C:6]2[S:5](=[O:12])(=[O:11])[N:4]=1.[CH3:13][N:14]([CH2:16][C:17]1[O:21][C:20]([CH2:22][S:23][CH2:24][CH2:25][NH2:26])=[CH:19][CH:18]=1)[CH3:15]>C(O)C>[CH3:15][N:14]([CH2:16][C:17]1[O:21][C:20]([CH2:22][S:23][CH2:24][CH2:25][NH:26][C:3]2[C:7]3=[CH:8][S:9][CH:10]=[C:6]3[S:5](=[O:11])(=[O:12])[N:4]=2)=[CH:19][CH:18]=1)[CH3:13]

참가 물질

4

반응물 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 13390866HCID 13390866, 화합물

생성물 1

HCID 178483223HCID 178483223, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of 1.8 g. (0.0082 m.) of 3-(methylthio)thieno[3,4-d]isothiazole-1,1-dioxide in 10 ml. of ethanol is added 1.76 g. (0.0082 m.) of 2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamine with stirring at room temperature. The reaction mixture is heated to reflux and heating is continued for 1.5 hours. At this time the reaction mixture is filtered to remove insoluble material and then evaporated to dryness. The product is purified using a silica gel column with methanol as the eluant. The desired fraction was evaporated to dryness and then triturated with ether to give 120 mg. a white solid with a m.p. 100°-103° C.

후처리

  1. additionTo a suspension of 1.8 g
  2. temperatureThe reaction mixture is heated
  3. temperatureto reflux
  4. temperatureheating
  5. filtrationAt this time the reaction mixture is filtered
  6. customto remove insoluble material
  7. customevaporated to dryness
  8. customThe product is purified
  9. customThe desired fraction was evaporated to dryness
  10. customtriturated with ether
  11. customto give 120 mg

출처 및 근거

ORD 기록
ord-33d63e5c425c4842825c98d7812a539a
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04490527

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