Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1154747생성일: 2026년 10월 25일
Dimethyl Sulfoxide → 2,4-Dihydro-4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-3H-1,2,4-triazol-3-one
https://huagongshe.com/reaction/1154747
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | Formamidine acetate | HCID 160693 | — |
| 반응물 | N-{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}hydrazinecarboxamide | HCID 820816 | — |
| 용매 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 생성물 | 2,4-Dihydro-4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-3H-1,2,4-triazol-3-one | HCID 4246597 | 28% |
반응 단계
A mixture of 3.4 parts of N-{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}hydrazinecarboxamide, 3 parts of methanimidamide acetate and 10 parts of dimethyl sulfoxide is stirred and heated for 2 hours at 100° C. The reaction mixture is cooled and poured onto a mixture of 4-methyl-2-pentanone and 2,2'-oxybispropane. The precipitated product is filtered off and crystallized from N,N-dimethylformamide (activated charcoal), yielding 1 part (28%) of 2,4-dihydro-4-{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}-3H-1,2,4-triazol-3-one; mp. +300° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04490530 |
|---|
| 출처 데이터셋 | uspto-grants-1984_12 |
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| ORD ID | ord-6997abedbd984d1b9ea5195c8b948bac |
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| 출처 메모 | uspto-grants-1984_12 |
|---|
