Water → Methyl 2-methoxy-5-phenylthiazole-4-carboxylate

HRID 1154754

반응식

HRID 1154754 반응식
Cl[C:2]1[S:3][C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:5]([C:7]([O:9][CH3:10])=[O:8])[N:6]=1.[CH3:17][O-:18].[Na+].O>CO>[CH3:17][O:18][C:2]1[S:3][C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:5]([C:7]([O:9][CH3:10])=[O:8])[N:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 12821997Methyl 2-chloro-5-phenyl-4-thiazolecarboxylate

생성물 1

HCID 12821998Methyl 2-methoxy-5-phenylthiazole-4-carboxylate수율 70%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Under a static N2 atm, a stirred solution of the compound of Example 2 (8.14 g, 32 mol) in 100 ml of methanol was treated dropwise with 7.6 g of 25% sodium methoxide in methanol. After stirring at ambient temperature for 24 hr, the mixture was added to H2O and extracted twice with ether. The ether layer was washed with H2O, dried over MgSO4 and concentrated in vacuo to yield a white solid which was recrystallized from methylcyclohexane to yield 5.5 g of methyl 2-methoxy-5-phenyl-4-thiazolecarboxylate as a white solid, m.p. 86°-88° C., yield 70%.

후처리

  1. extractionextracted twice with ether
  2. washThe ether layer was washed with H2O
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customto yield a white solid which
  6. customwas recrystallized from methylcyclohexane

출처 및 근거

ORD 기록
ord-5f6a3c5eff844e1baa0a0ffcf4eb85ae
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04298375

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