Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isobutylamine → 7-amino-2,2-dimethyl-8-(2-methylpropyl)-6-nitroso-3H-imidazo[1,2-a]pyrimidin-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isobutylamine | HCID 6558 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Chlorobenzylamine | HCID 66036 | — |
| 반응물 | Sodium dithionate | HCID 146045 | — |
| 반응물 | Ethyl 2-cyano-2-(hydroxyimino)acetate | HCID 6399078 | — |
| 반응물 | HCID 178448423 | HCID 178448423 | — |
| 반응물 | 2-Methylthio-4,4-dimethyl-2-imidazoline hydrochloride | HCID 178503443 | — |
| 용매 | Formic Acid | HCID 284 | — |
| 생성물 | 7-amino-2,2-dimethyl-8-(2-methylpropyl)-6-nitroso-3H-imidazo[1,2-a]pyrimidin-5-one | HCID 178448424 | — |
반응 단계
6,7-DIHYDRO-4-(2METHYLPROPYL)-6,6-DIMETHYL-3H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE.-- 7-Amino-2,3-dihydro-2,2-dimethyl-8-(2-methylpropyl)-6-nitrosoimidazo[1,2-a]pyrimidin-5(8H)-one was prepared by reaction of the 2-methylthio-4,4-dimethyl-2-imidazoline hydrochloride with 2-methylpropylamine according to the method of Procedure 103 by substitution of the latter for p-chlorobenzylamine. The reaction product from this step was then condensed with ethyl oximinocyanoacetate as described in Procedure 103. The resulting nitroso compound was then reduced with sodium dithionate in formic acid and the resulting formylamino compound was cyclized with dilute aqueous sodium hydroxide according to Procedure 100.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04298734 |
| 출처 데이터셋 | uspto-grants-1981_11 |
| ORD ID | ord-919ec093ce254ff6b83298a0c56dee4c |
| 출처 메모 | uspto-grants-1981_11 |