Hydrogen Peroxide → 1H-Purine, 8-(2-methoxy-4-(methylsulfinyl)phenyl)-

HRID 1155070노트

반응식

HRID 1155070 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1.[OH:20]O>FC(F)(F)C(O)=O.O.C(=O)([O-])[O-].[K+].[K+]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9]([CH3:10])=[O:20])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1

참가 물질

6

반응물 2

HCID 784Hydrogen PeroxideHCID 30599131H-Purine, 8-(2-methoxy-4-(methylthio)phenyl)-

생성물 1

HCID 30599181H-Purine, 8-(2-methoxy-4-(methylsulfinyl)phenyl)-

시약·촉매·용매 3

HCID 962Water용매HCID 6422Trifluoroacetic acid용매HCID 11430Potassium Carbonate용매

반응 조건

온도
5 °C

실험 절차

An amount of 2.27 g of 8-(2-methoxy-4-methylmercaptophenyl)-purine was dissolved in 20 ml of trifluoro acetic acid, and 1.2 ml of 30% hydrogen peroxide were added under cooling to 5° C. After stirring for 3 hours at room temperature and for 0.5 hours at 30° C., the reaction mixture was diluted with water and neutralized with potassium carbonate, and the residue obtained after evaporation was extracted with hot ethanol. The product obtained was purified over silicagel (eluate: methylene chloride/ethanol in a volume ratio of 19:1).

후처리

  1. customthe residue obtained
  2. customafter evaporation
  3. extractionwas extracted with hot ethanol
  4. customThe product obtained
  5. customwas purified over silicagel (eluate: methylene chloride/ethanol in a volume ratio of 19:1)

출처 및 근거

ORD 기록
ord-507cfd61a71a486b945608256e6bcdcb
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04299834

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