(R)-1-Cbz-2-(aminocarbonyl)piperidine → 2-Piperidinecarboxamide, (R)-

HRID 1155088노트

반응식

HRID 1155088 반응식
[N:1]1(C(OCC2C=CC=CC=2)=O)[CH2:9][CH2:8][CH2:7][CH2:6][C@@H:2]1[C:3]([NH2:5])=[O:4]>CO.[Pd]>[NH:1]1[CH2:9][CH2:8][CH2:7][CH2:6][C@@H:2]1[C:3]([NH2:5])=[O:4]

참가 물질

4

반응물 1

HCID 27281977(R)-1-Cbz-2-(aminocarbonyl)piperidine

생성물 1

HCID 70621612-Piperidinecarboxamide, (R)-수율 90%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

3.93 g (15 mmoles) of Z-D-Pip-NH2 are dissolved in 75 ml of methanol, 0.5 g of a 10% palladium-on-carbon catalyst are added, and hydrogen is bubbled through the mixture for one hour. The catalyst is filtered off, the filtrate is evaporated, and the residue is triturated with ether. 1.70 g (90%) of H-D-Pip-NH2 are obtained: m.p.: 161°-163° C., Rf4 =0.10, [α]D25 =+31.0° (c=1%, in methanol).

후처리

  1. customhydrogen is bubbled through the mixture for one hour
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated
  4. customthe residue is triturated with ether

출처 및 근거

ORD 기록
ord-7dd3a3e75d6742c6a4f17365b3891bef
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04299821

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