Potassium Carbonate → 2-(1,4-BENZODIOXAN-2YL)-METHYLENE-BENZIMIDAZOLE

HRID 1155294노트

반응식

HRID 1155294 반응식
Cl.[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][C:13]1[NH:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][C:13]1[NH:17][C:16]2[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=2[N:14]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 12761781HCID 12761781, 화합물

생성물 1

HCID 127617802-(1,4-BENZODIOXAN-2YL)-METHYLENE-BENZIMIDAZOLE

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

2-(1,4-benzodioxan-2-ylmethyl)benzimidazole hydrochloride (1.0 g) suspended in 50 ml of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 2-(1,4-benzodioxan-2-ylmethyl)benzimidazole.

후처리

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-54f10b772d3b4f11b68bee647f30b9b3
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04301171

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