참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1,4-Dihydro-2H-3,1-benzoxazin-2-one | HCID 25786 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Isopropyl Acetate | HCID 7915 | — |
| 생성물 | 2-Aminobenzyl alcohol | HCID 21439 | — |
반응 단계
The reaction mixture from Stage A was boiled so as to drive off the isopropyl acetate solvent. A solution of 100 g of sodium hydroxide in 100 ml of water was added to the residue, and the whole was refluxed for 2 hours. After cooling to 45° C., the product was extracted with four 270 ml portions of isopropyl acetate. The isopropyl acetate was then distilled off and the product recrystallized from toluene to give 100 g (63% of theoretical) of 97-98% pure 2-amino-benzyl alcohol; m.p. 83°-83.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04301283 |
|---|
| 출처 데이터셋 | uspto-grants-1981_11 |
|---|
| ORD ID | ord-caa27b79386f449a895ea5d3d2f83872 |
|---|
| 출처 메모 | uspto-grants-1981_11 |
|---|
