홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Methanol → 2-Methyl-6,7-dimethoxy-1[4,5,6-triethoxy-7-nitro-3-phthalidyl]-1,2,3,4-tetrahydro-isoquinoline

HRID 1155506
노트
인쇄 미리보기

반응식

HRID 1155506 반응식
[I-].[CH3:2][N+:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][C:7]([O:15][CH3:16])=[C:8]([O:13][CH3:14])[CH:9]=2)[CH:4]=1.[CH2:17]([O:19][C:20]1[C:29]([O:30][CH2:31][CH3:32])=[C:28]([O:33][CH2:34][CH3:35])[C:27]([N+:36]([O-:38])=[O:37])=[C:26]2[C:21]=1[CH2:22][O:23][C:24]2=[O:25])[CH3:18].C(=O)([O-])[O-].[K+].[K+].CO>O>[CH3:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][C:7]([O:15][CH3:16])=[C:8]([O:13][CH3:14])[CH:9]=2)[CH:4]1[CH:22]1[C:21]2[C:26](=[C:27]([N+:36]([O-:38])=[O:37])[C:28]([O:33][CH2:34][CH3:35])=[C:29]([O:30][CH2:31][CH3:32])[C:20]=2[O:19][CH2:17][CH3:18])[C:24](=[O:25])[O:23]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 887MethanolHCID 11430Potassium CarbonateHCID 28269906,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium iodideHCID 64521774,5,6-Triethoxy-7-nitrophthalide

생성물 1

HCID 205609802-Methyl-6,7-dimethoxy-1[4,5,6-triethoxy-7-nitro-3-phthalidyl]-1,2,3,4-tetrahydro-isoquinoline

시약·촉매·용매 1

HCID 962
Water
용매

실험 절차

200 g (0.6 mole) of 2-methyl-6,7-dimethoxy-3,4-dihydro-isoquinolinium iodide (prepared in the same manner as the compound of Example A) 186 g of 4,5,6-triethoxy-7-nitrophthalide and 100 g of potassium carbonate are added to 1.5 l of methanol while stirring. The reaction mixture is stirred for 24 hours at a temperature below the boiling point of the solvent, and is then allowed to cool; 900 ml of water is added and the reaction solution is allowed to crystallise. The solution is filtered, rinsed with methanol, and then with water.

후처리

  1. stirringThe reaction mixture is stirred for 24 hours at a temperature below the boiling point of the solvent
  2. temperatureto cool
  3. customto crystallise
  4. filtrationThe solution is filtered
  5. washrinsed with methanol

출처 및 근거

ORD 기록
ord-bc17c10b4dd148d4aaee83389a8f65d7
출처 데이터셋
uspto-grants-1981_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04302458

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트