Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → 4-(2-Chloro-5-pyridylmethyloxy)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4-(2-Chloro-5-pyridylmethyloxy)nitrobenzene | HCID 20537915 | — |
| 촉매 | Iron | HCID 23925 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-(2-Chloro-5-pyridylmethyloxy)aniline | HCID 20537895 | — |
반응 단계
Two grams (7.6 mmol) of 2-chloro-5-(4-nitrophenoxy) methylpyridine and 4 grams (76.0 mmol) of ammonium chloride in 40 ml of ethanol and 20 ml of water are heated to 60°, after which 2.1 grams (38.0 mmol) of iron powder is added in small portions over 15 minutes. The mixture is heated under reflux for 2 hours. The reaction is cooled and stripped, and the residue is taken up in ether, washed with water, dried over sodium sulfate and stripped to yield 2-chloro-5-(4-aminophenoxy)methylpyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04332944 |
| 출처 데이터셋 | uspto-grants-1982_06 |
| ORD ID | ord-da7d36f6837a467daddd828cc96beede |
| 출처 메모 | uspto-grants-1982_06 |