Methanol → 3-[2-(2-Cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole

HRID 1155778노트

반응식

HRID 1155778 반응식
[C:1]([N:3]=[C:4]([NH:19][CH3:20])[NH:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[N:14]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[S:12][N:11]=1)#[N:2].I([O-])(=O)(=O)=[O:22].[Na+].CO>O>[C:1]([N:3]=[C:4]([NH:19][CH3:20])[NH:5][CH2:6][CH2:7][S:8]([CH2:9][C:10]1[N:14]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[S:12][N:11]=1)=[O:22])#[N:2]

참가 물질

5

반응물 3

HCID 887MethanolHCID 23667635Sodium periodateHCID 178485071HCID 178485071, 화합물

생성물 1

HCID 1784850733-[2-(2-Cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3-[2-(2-cyano-3-methylguanidino)-ethylthiomethyl]-5-guanidino-1,2,4-thiadiazole (0.626 g.), sodium metaperiodate (0.428 g.), methanol (20 ml.) and water (70 ml.) was stirred overnight at room temperature. The reaction mixture was evaporated to dryness and the residue extracted with absolute ethanol (120 ml.). The extract was filtered and evaporated to dryness. The residue was crystallised from methanol (with charcoal treatment) to give 3-[2-(2-cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole as a white powder, m.p. 185°-186°.

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. extractionthe residue extracted with absolute ethanol (120 ml.)
  3. filtrationThe extract was filtered
  4. customevaporated to dryness
  5. customThe residue was crystallised from methanol (with charcoal treatment)

출처 및 근거

ORD 기록
ord-9cbde29e005c45d49513d51444c12fed
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04332949

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