Dimethylformamide → 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran-2-one

HRID 1155947노트

반응식

HRID 1155947 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[C:7]([CH3:12])([CH3:11])[C:6]=2[CH:13]=1.[CH3:14][N:15](C)C=O>>[C:14]([C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[C:7]([CH3:12])([CH3:11])[C:6]=2[CH:13]=1)#[N:15]

참가 물질

3

반응물 2

HCID 6228DimethylformamideHCID 162206345-Bromo-3,3-dimethylbenzofuran-2(3H)-one

생성물 1

HCID 205362475-Cyano-2,3-dihydro-3,3-dimethylbenzofuran-2-one수율 45%

실험 절차

5-Bromo-2,3-dihydro-3,3-dimethylbenzofuran-2-one (39.2 g, 0.162 mole) was treated with cuprous cyanide (17.9 g, 0.2 mole) in dimethyl formamide (40 ml) (as in example 2). Recrystallisation (twice) of the product from ethanol yielded 14 g (45%) title product m.p. 138°-140° C.

후처리

  1. customRecrystallisation (twice) of the product from ethanol

출처 및 근거

ORD 기록
ord-0752ff598b194c4ab962419e8838d10a
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04333759

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