Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → 2-(2-Methoxy-5-cyanophenyl)-2-methyl-1-propanal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 2-(5-Bromo-2-methoxyphenyl)-2-methylpropanal | HCID 20536223 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(2-Methoxy-5-cyanophenyl)-2-methyl-1-propanal | HCID 20536256 | — |
반응 단계
2-(2-Methoxy-5-bromophenyl)-2-methyl-1-propanal (9.5 g), prepared as in Example 5(d), cuprous cyanide (4.0 g) and dimethylformamide (20 ml) were heated under reflux with stirring for 3 hours. A solution of ferric chloride (7.3 g) in water (25 ml) and hydrochloric acid (3.5 ml conc) was added to the cooled reaction mixture which was then heated at 60°-70° C. for 5 minutes. Isolation of the product through diethyl ether yielded, after recrystallisation from ethanol, 3 g of pure product, mp 115°-117° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04333759 |
| 출처 데이터셋 | uspto-grants-1982_06 |
| ORD ID | ord-07b1f9054299492899c6c5d2a13c790b |
| 출처 메모 | uspto-grants-1982_06 |