Thionyl Chloride → 2,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid chloride

반응식

[CH3:1][C:2]1([CH3:14])[C:6]2[CH:7]=[C:8]([C:11](O)=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1.S(Cl)([Cl:17])=O>>[CH3:1][C:2]1([CH3:14])[C:6]2[CH:7]=[C:8]([C:11]([Cl:17])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 220413993,3-Dimethyl-2,3-dihydro-1-benzofuran-5-carboxylic acid

생성물 1

HCID 545007362,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid chloride수율 127.7%

실험 절차

The product of stage (a) (3 g) was boiled under reflux in thionyl chloride (3.6 g) for 3 hours. Removal of the thionyl chloride under vacuum gave crude title product (4.2 g).

후처리

customRemoval of the thionyl chloride under vacuum

출처 및 근거

ORD 기록: ord-560dd71c069546a9a987d6359913eef5
출처 데이터셋: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04333759

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