Ammonia → 2,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid amide

반응식

[CH3:1][C:2]1([CH3:14])[C:6]2[CH:7]=[C:8]([C:11](Cl)=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1.[NH3:15]>>[CH3:1][C:2]1([CH3:14])[C:6]2[CH:7]=[C:8]([C:11]([NH2:15])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1

참가 물질

반응물 2

HCID 222Ammonia

HCID 545007362,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid chloride

생성물 1

HCID 540896312,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid amide

실험 절차

The product of stage (b) (4.2 g) was added dropwise to excess aqueous ammonia with stirring and ice cooling. After 1 hour the white precipitate was filtered off and recrystallised from ethanol to give 1.1 g of title product, mp 136°-138° C.

후처리

filtrationAfter 1 hour the white precipitate was filtered off
customrecrystallised from ethanol

출처 및 근거

ORD 기록: ord-1bf2508ee087481386050f91d455139e
출처 데이터셋: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04333759

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