Potassium Carbonate → HCID 70543145, 화합물

HRID 1156174노트

반응식

HRID 1156174 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]3[CH:10]=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[CH:12]=[CH:13][C:7]=3[C:6]=2[CH:18]=1.C(=O)([O-])[O-].[K+].[K+].Cl.[CH3:26][N:27]([CH2:29][CH2:30]Cl)[CH3:28]>CN(C)C=O>[ClH:1].[CH3:26][N:27]([CH3:28])[CH2:29][CH2:30][O:16][C:15](=[O:17])[CH2:14][C:11]1[CH:12]=[CH:13][C:7]2[C:6]3[CH:18]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[S:9][C:8]=2[CH:10]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 130651048-Chlorodibenzothiophene-3-acetic acid

생성물 1

HCID 70543145HCID 70543145, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2.76 g. of 8-chlorodibenzothiophene-3-acetic acid, 3.04 g. of potassium carbonate, 1.73 g. of dimethylaminoethyl chloride hydrochloride, and 250 ml. of dimethylformamide was stirred and heated at 120° for 4 hours. The solvent was removed in vacuo on the steam bath, and 75 ml. of water added to the residue. The oil was extracted with ethyl acetate and the crude product precipitated as the hydrochloride by the addition of hydrogen chloride. On crystallization from acetone, 1.5 g. of 8-chlorodibenzothiophene-3-acetic acid 2-dimethylaminoethyl ester hydrochloride, m.p. 179°-181°, was obtained.

후처리

  1. additionA mixture of 2.76 g
  2. temperatureheated at 120° for 4 hours
  3. customThe solvent was removed in vacuo on the steam bath, and 75 ml
  4. additionof water added to the residue
  5. extractionThe oil was extracted with ethyl acetate
  6. customthe crude product precipitated as the hydrochloride by the addition of hydrogen chloride
  7. customOn crystallization from acetone, 1.5 g

출처 및 근거

ORD 기록
ord-c88c0a5218804a50aafec4f596fdd1d2
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04334078

반응 노트

불러오는 중…