3-Bromo-1-(trimethylsilyl)-1-propyne → Methyl [6,7-dichloro-1-oxo-2-phenyl-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate

HRID 1156190노트

반응식

HRID 1156190 반응식
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][CH:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:8]2=[O:12])=[CH:4][C:3]=1[O:19][CH2:20][C:21]([O:23][CH3:24])=[O:22].Br[CH2:26][C:27]#[C:28][Si:29]([CH3:32])([CH3:31])[CH3:30]>C1CCCCC1.C(Cl)Cl>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)([CH2:26][C:27]#[C:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[C:8]2=[O:12])=[CH:4][C:3]=1[O:19][CH2:20][C:21]([O:23][CH3:24])=[O:22]

참가 물질

4

반응물 2

HCID 6425893-Bromo-1-(trimethylsilyl)-1-propyneHCID 12774096Methyl (6,7-dichloro-1-oxo-2-phenyl-5-indanyloxy)acetate

생성물 1

HCID 12774092Methyl [6,7-dichloro-1-oxo-2-phenyl-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate수율 74%

시약·촉매·용매 1

HCID 21916607Dichloromethane cyclohexane용매

실험 절차

Reaction of methyl (6,7-dichloro-1-oxo-2-phenyl-5-indanyloxy)acetate with 1-bromo-3-(trimethylsilyl)-2-propyne according to Example 1, STEP (b), affords the title compound, m.p. 125.5°-127° (from cyclohexane-methylene chloride) in 74% yield.

출처 및 근거

ORD 기록
ord-821c80682b2a44e883a66372506427cb
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04334088

반응 노트

불러오는 중…