Water → Ethyl N-(2,2,2-trifluoroethyl)formimidate

HRID 1156233노트

반응식

HRID 1156233 반응식
Cl.[CH:2](=[NH:6])[O:3][CH2:4][CH3:5].Cl.[F:8][C:9]([F:13])([F:12])[CH2:10]N.C(=O)([O-])[O-].[K+].[K+].O>C(Cl)Cl>[F:8][C:9]([F:13])([F:12])[CH2:10][N:6]=[CH:2][O:3][CH2:4][CH3:5]

참가 물질

6

반응물 4

HCID 962WaterHCID 97722,2,2-Trifluoroethylamine hydrochlorideHCID 11430Potassium CarbonateHCID 12578842Ethyl formimidate hydrochloride

생성물 1

HCID 20535620Ethyl N-(2,2,2-trifluoroethyl)formimidate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Ethyl formimidate hydrochloride (0.555 g, 5 mmole), 2,2,2-trifluoroethylamine hydrochloride (0.677 g, 5 mmole) and potassium carbonate (0.345 g, 2.5 mmole) are suspended in 20 ml CH2Cl2 and treated with 2 ml H2O. The mixture is shaken vigorously for 3 minutes. The organic phase is separated and the aqueous extracted twice with 10 ml portions of CH2Cl2The combined organic phase is dried and the CH2Cl2 distilled through a Vigreauxe column to give the Ethyl N-(2,2,2-trifluoroethyl)formimidate. n.m.r. δ1.33 t (CH3CH2); 3.8 q (j=10 c.p.s., CF3CH2) 4.23 q (j=7.5, CH3CH2O); 7.6 S (H--C=N).

후처리

  1. customThe organic phase is separated
  2. extractionthe aqueous extracted twice with 10 ml portions of CH2Cl2The combined organic phase
  3. customis dried
  4. distillationthe CH2Cl2 distilled through a Vigreauxe column

출처 및 근거

ORD 기록
ord-fba44a89d9a146369bd332f91d3b6b6e
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04335043

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