2-Bromoethanol → 2-[4-(2-hydroxyethoxy)phenyl]acetonitrile

HRID 1156269노트

반응식

HRID 1156269 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.Br[CH2:12][CH2:13][OH:14].C(=O)([O-])[O-].[K+].[K+]>CC(CC)=O>[OH:14][CH2:13][CH2:12][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 108982-BromoethanolHCID 11430Potassium Carbonate2회HCID 265484-Hydroxybenzyl cyanide

생성물 1

HCID 205357162-[4-(2-hydroxyethoxy)phenyl]acetonitrile

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

5 g p-hydroxyphenylacetonitrile were dissolved in 250 ml methylethylketone. 7 g of 2-bromoethanol and 23 g potassium carbonate were added thereto. The mixture was stirred for 48 hours under reflux. At the end of the reaction the potassium carbonate and the produced potassium bromide were filtered. The precipitates were washed with acetone and the acetone wash was added to the reaction mixture. The clear solution was reduced to about 10-15 ml. It was then taken up in ether and shaken with 1/100 N sodium hydroxide.

후처리

  1. temperatureunder reflux
  2. filtrationthe produced potassium bromide were filtered
  3. washThe precipitates were washed with acetone
  4. washthe acetone wash
  5. additionwas added to the reaction mixture
  6. stirringshaken with 1/100 N sodium hydroxide

출처 및 근거

ORD 기록
ord-047de5666281495d9b1c7b4f58342c0b
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04335119

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