Triethylamine → HCID 20278953, 화합물

HRID 1156333노트

반응식

HRID 1156333 반응식
Cl[CH2:2][CH2:3][CH2:4][C:5]([NH:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([NH2:12])=[O:11])=[O:6].Cl.[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[O:26])=[CH:21][CH:20]=1.C(N(CC)CC)C>C(#N)C>[NH2:12][C:10]([C:9]1[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=1[NH:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2][N:30]1[CH2:31][CH2:32][CH:27]([C:25](=[O:26])[C:22]2[CH:21]=[CH:20][C:19]([F:18])=[CH:24][CH:23]=2)[CH2:28][CH2:29]1)=[O:11]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2643092-[(4-Chlorobutanoyl)amino]benzamideHCID 3084438p-Fluorophenyl 4-piperidyl ketone hydrochloride

생성물 1

HCID 20278953HCID 20278953, 화합물수율 81%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 7.2 parts of 2-[(4-chloro-1-oxobutyl)amino]benzamide, 7.3 parts of (4-fluorophenyl) (4-piperidinyl)methanone hydrochloride, 10.1 parts of N,N-diethylethanamine and 120 parts of acetonitrile is stirred and refluxed for 24 hours. The reaction mixture is evaporated and water is added to the residue. The oily product is extracted with trichloromethane. The extract is dried, filtered and evaporated, yielding 10 parts (81%) of N-[2-(aminocarbonyl)phenyl]-4-(4-fluorobenzoyl)-1-piperidinebutanamide as a residue.

후처리

  1. temperaturerefluxed for 24 hours
  2. customThe reaction mixture is evaporated
  3. additionwater is added to the residue
  4. extractionThe oily product is extracted with trichloromethane
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-a539135aa3f94469beec61211af5ccea
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04335127

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