Acetic Acid → HCID 13476541, 화합물

HRID 1156342노트

반응식

HRID 1156342 반응식
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=O.C(O)(=O)C.[O-:19][C:20]#[N:21].[K+]>O>[OH:1][CH2:2][CH2:3][N:4]1[C:5]2[C:6](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:7](=[O:9])[NH:21][C:20]1=[O:19]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 269008methyl 2-[(2-hydroxyethyl)amino]benzoateHCID 11378442Potassium cyanate

생성물 1

HCID 13476541HCID 13476541, 화합물수율 48%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred mixture of 10 parts of methyl 2-[(2-hydroxyethyl)amino]benzoate and 100 parts of acetic acid is added dropwise a solution of 4.5 parts of potassium cyanate in 25 parts of water. Upon completion, stirring at room temperature is continued overnight. The reaction mixture is evaporated. The solid residue is stirred with water. The product is filtered off, washed with water and ethanol, and dried, yielding 5 parts (48%) of 1-(2-hydroxyethyl)-2,4(1H,3H)-quinazolinedione; mp. 273.6° C.

후처리

  1. customThe reaction mixture is evaporated
  2. stirringThe solid residue is stirred with water
  3. filtrationThe product is filtered off
  4. washwashed with water and ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-63f4e0bb06aa449c951dca18e7c9ab6e
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04335127

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