L-Valine → N-{(2-chloroethyl)-nitrosocarbamoyl}-L-valine
반응식
[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4].O1CCCC1.[Cl:14][CH2:15][CH2:16][N:17]([N:23]=[O:24])[C:18](N=[N+]=[N-])=[O:19]>C(=O)([O-])[O-].[K+].[K+]>[Cl:14][CH2:15][CH2:16][N:17]([N:23]=[O:24])[C:18]([NH:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4])=[O:19]참가 물질
5
실험 절차
Dissolved in a 5% aqueous potassium carbonate solution was 2.1 g of L-valine, and a tetrahydrofuran solution containing 3.2 g of (2-chloroethyl)-nitrosocarbamoyl azide was added at 0° C. The mixture was stirred for two hours. The reaction solution was washed with ether, neutralized with hydrochloric acid, and extracted with ether to obtain 2.9 g (Yield 64%) of N-{(2-chloroethyl)-nitrosocarbamoyl}-L-valine as a slightly yellow oil.
후처리
- additionwas added at 0° C
- washThe reaction solution was washed with ether
- extractionextracted with ether
출처 및 근거
- ORD 기록
- ord-510809cdb5434556a861e4f912d8465c
- 출처 데이터셋
- uspto-grants-1982_06
- 특허 번호
- US04335247
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